I do all of my production work on Arch-based Linux systems these days. This is generally a pleasent experience since Reaper started supporting native Linux builds and yabridgectl made bridging Windows VST Plugins quite breezy and effective. Once setup correctly, this offers a performance experience and workflow that I think is quite close to native. One advice that I kept hearing again and again though was to install wine (the Wine program that lets you use Windows software on Linux) using wine-tkg, a customized build system for installing.
One of the big hurdles for me when switching from a Mac based audio setup was the potential loss of access to my expensive collection of VST plugins (because a lot of developers still ignore the Linux platform as if it was 1995 even though it has never been easier to make and release cross platform plugins). Little did I know that almost all of them would run just fine on Linux using the wine Windows compatibility layer and the yabridge or linvst VST plugin bridging software.